Studies on proteins secreted by isoproterenol from rat parotid tissues briefly with agonist.
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چکیده
منابع مشابه
Properties of proline-rich proteins from parotid glands of isoproterenol-treated rats.
This report describes the physical and chemical properties of a series of proline-rich proteins isolated from parotid glands of isoproterenol-treated rats. As described previously (Muenzer, J., Bildstein, C., Gleason, M., and Carlson, D. M. (1979) J. Biol. Chem. 254, 56235628), a dramatic increase in these proteins occurs concomitantly with hyperplasia and hypertrophy of parotid glands of rats ...
متن کاملPurification of proline-rich proteins from parotid glands of isoproterenol-treated rats.
Prolonged isoproterenol treatment of rats is known to cause hypertrophy and hyperplasia of the parotid glands. Our results show that a dramatic increase in the synthesis or accumulation in the parotid glands of a series of proteins rich in proline also occurs with isoproterenol treatment. After 10 days of treatment (5 mg of isoproterenol/day) these proline-rich proteins (PRPs) comprise more tha...
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The main sulphated proteins secreted by rat mammary gland tissue have Mr of approximately 32 000, 27 000 and 25 000 Da. In addition, there are high Mr components which have a diffuse electrophoretic mobility (Mr > 200 000) and most likely corresponded to proteoglycans. The sulphate groups in the proteins with discrete Mr are most likely all linked to carbohydrates. These sulphated molecules wer...
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The effects of three calmodulin antagonists on rat parotid amylase release were investigated in vitro using a dispersed acinar cell preparation. The potent calmodulin antagonists, trifluoperazine (TFP) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), inhibited both 1 microM isoproterenol (ISO)- and 1 mM dibutyryl cyclic AMP (DBcAMP)-stimulated amylase release in a dose-dependent ma...
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We have studied the postnatal alterations of the neurotransmitter receptors in rat parotid gland, and found that the number of ƒÀ-adrenoceptors in the tissues and their affinity for the ƒÀ-agonists increased significantly during development and that these changes were coupled with amylase secretion by ƒÀ-agonist from the tissues. In this experiment, developmental changes in the adenylate cyclas...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51887-x